Advanced Instrumentation, Data Interpretation, and Control by J.F. van Impe, P.A. Vanrolleghem, D.M. Iserentant PDF

By J.F. van Impe, P.A. Vanrolleghem, D.M. Iserentant

ISBN-10: 9048149541

ISBN-13: 9789048149544

The scope of the sector of biotechnological techniques is particularly large, overlaying such methods as fermentations for construction of high-valued expert chemical substances (e.g. pharmaceuticals), high-volume construction of meals and feeds (e.g. yoghurt, cheese, beer), in addition to organic waste therapy, dealing with reliable (composting), liquid (activated sludge) and gaseous wastes (biofilters). in comparison to different engineering disciplines, the creation of recent optimization and keep watch over suggestions is lagging in the back of. major purposes might be pointed out. First, the dwelling organisms (or half thereof) which are significant to those procedures make the mathematical modeling of the procedures a tough job, and, in view that versions are vital to the advance of keep watch over platforms, the online regulate challenge is additionally complicated. the opposite trouble stems from the absence, mostly, of inexpensive and trustworthy instrumentation suited for real-time monitoring.
In this ebook a couple of complex concepts is brought to house those difficulties. within the first half glossy online sensors are mentioned intimately (FIA, plausible biomass dimension, membrane inlet mass spectrometry, stream cytometry, microcalorimetry). within the moment half, novel model-based method prognosis and keep an eye on thoughts are handled, together with advances in bioprocess modeling and id, information processing, software program sensor layout, and online keep watch over algorithms.
The booklet is directed at engineers, researchers, and scholars within the box of approach regulate and structures thought as utilized to business biotechnological techniques, in addition to at bioengineers who've a few history up to speed engineering and want to extend their knowing of ways complex keep an eye on idea applies to organic methods.

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The scope of the sphere of biotechnological methods is especially extensive, masking such tactics as fermentations for creation of high-valued professional chemical compounds (e. g. pharmaceuticals), high-volume creation of meals and feeds (e. g. yoghurt, cheese, beer), in addition to organic waste remedy, dealing with stable (composting), liquid (activated sludge) and gaseous wastes (biofilters).

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FIA can be expected to become one of the most powerful tools for quantitative bioprocess monitoring in the near future provided that non-linear calibration models are also used and that data evaluation techniques improve [43, 114, 166, 185, 259]. Wu 28 B. Sonnleitner and Bellgardt [466, 467] were able to detect faults in the analytical system automatically. The present tendency is towards using multi-channel FIA systems that work either in parallel or with sequential injection [20, 283, 446, 469], miniaturization of FIA devices [48, 144, 420, 421], and automation [112, 171, 172, 321].

A similar approach is used with surface acoustic wave detectors [142] or with the surface plasmon resonance technology (BIAcore, Pharmacia). Generally, biosensors are tricky to handle. g. an enzyme or a living microorganism [208, 209], they principally cannot be sterilized. They also suffer from changes in the environment, for example, changes in pH or formation of aggressive chemicals such as H2 O2 [342]. They must therefore be used in a suitable environment, preferably after sample preparation as in an FIA system.

336]. A control loop based on H2 measurements has been set up by Lloyd and Whitmore [243] and Whitmore et al. [457] in order to prevent inhibition of methanogenesis: they controlled the addition of the carbon source to a thermophilic anaerobic digestion process. Even linked pO2 , pH and OUR control are reported based on direct mass spectrometric measurements [103, 312]. There are no reports currently available of an on-line application of the very powerful MALDI technique (matrix-assisted laser desorption/ionization time-of-flight mass spectrometry).

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Advanced Instrumentation, Data Interpretation, and Control of Biotechnological Processes by J.F. van Impe, P.A. Vanrolleghem, D.M. Iserentant


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